The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.
Identifieur interne : 004596 ( Main/Exploration ); précédent : 004595; suivant : 004597The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.
Auteurs : Julian A. Tanner [République populaire de Chine] ; Bo-Jian Zheng ; Jie Zhou ; Rory M. Watt ; Jie-Qing Jiang ; Kin-Ling Wong ; Yong-Ping Lin ; Lin-Yu Lu ; Ming-Liang He ; Hsiang-Fu Kung ; Andreas J. Kesel ; Jian-Dong HuangSource :
- Chemistry & biology [ 1074-5521 ] ; 2005.
Descripteurs français
- KwdFr :
- Adamantane (), Adamantane (analogues et dérivés), Adamantane (pharmacologie), Animaux, Antienzymes (), Antienzymes (pharmacologie), Antiviraux (), Antiviraux (pharmacologie), Cellules cultivées, Helicase (antagonistes et inhibiteurs), Helicase (métabolisme), Macaca mulatta, Pyridines (), Pyridines (pharmacologie), Relation dose-effet des médicaments, Réplication virale (), Réplication virale (physiologie), Virus du SRAS (), Virus du SRAS (enzymologie), Virus du SRAS (physiologie).
- MESH :
- analogues et dérivés : Adamantane.
- antagonistes et inhibiteurs : Helicase.
- enzymologie : Virus du SRAS.
- métabolisme : Helicase.
- pharmacologie : Adamantane, Antienzymes, Antiviraux, Pyridines.
- physiologie : Réplication virale, Virus du SRAS.
- Adamantane, Animaux, Antienzymes, Antiviraux, Cellules cultivées, Macaca mulatta, Pyridines, Relation dose-effet des médicaments, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Adamantane (analogs & derivatives), Adamantane (chemistry), Adamantane (pharmacology), Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cells, Cultured, DNA Helicases (antagonists & inhibitors), DNA Helicases (metabolism), Dose-Response Relationship, Drug, Enzyme Inhibitors (chemistry), Enzyme Inhibitors (pharmacology), Macaca mulatta, Pyridines (chemistry), Pyridines (pharmacology), SARS Virus (drug effects), SARS Virus (enzymology), SARS Virus (physiology), Virus Replication (drug effects), Virus Replication (physiology).
- MESH :
- chemical , analogs & derivatives : Adamantane.
- chemical , antagonists & inhibitors : DNA Helicases.
- chemical , chemistry : Adamantane, Antiviral Agents, Enzyme Inhibitors, Pyridines.
- chemical , metabolism : DNA Helicases.
- chemical , pharmacology : Adamantane, Antiviral Agents, Enzyme Inhibitors, Pyridines.
- drug effects : SARS Virus, Virus Replication.
- enzymology : SARS Virus.
- physiology : SARS Virus, Virus Replication.
- Animals, Cells, Cultured, Dose-Response Relationship, Drug, Macaca mulatta.
Abstract
Bananins are a class of antiviral compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative. Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 microM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 microM and a CC50 of over 300 microM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.
DOI: 10.1016/j.chembiol.2005.01.006
PubMed: 15797214
Affiliations:
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Tanner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name></author><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name></author><author><name sortKey="Watt, Rory M" sort="Watt, Rory M" uniqKey="Watt R" first="Rory M" last="Watt">Rory M. 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Six members of this class of compounds: bananin, iodobananin, vanillinbananin, ansabananin, eubananin, and adeninobananin were synthesized and tested as inhibitors of the SARS Coronavirus (SCV) helicase. Bananin, iodobananin, vanillinbananin, and eubananin were effective inhibitors of the ATPase activity of the SCV helicase with IC50 values in the range 0.5-3 microM. A similar trend, though at slightly higher inhibitor concentrations, was observed for inhibition of the helicase activities, using a FRET-based fluorescent assay. In a cell culture system of SCV, bananin exhibited an EC50 of less than 10 microM and a CC50 of over 300 microM. Kinetics of inhibition are consistent with bananin inhibiting an intracellular process or processes involved in SCV replication.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="He, Ming Liang" sort="He, Ming Liang" uniqKey="He M" first="Ming-Liang" last="He">Ming-Liang He</name><name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name><name sortKey="Jiang, Jie Qing" sort="Jiang, Jie Qing" uniqKey="Jiang J" first="Jie-Qing" last="Jiang">Jie-Qing Jiang</name><name sortKey="Kesel, Andreas J" sort="Kesel, Andreas J" uniqKey="Kesel A" first="Andreas J" last="Kesel">Andreas J. Kesel</name><name sortKey="Kung, Hsiang Fu" sort="Kung, Hsiang Fu" uniqKey="Kung H" first="Hsiang-Fu" last="Kung">Hsiang-Fu Kung</name><name sortKey="Lin, Yong Ping" sort="Lin, Yong Ping" uniqKey="Lin Y" first="Yong-Ping" last="Lin">Yong-Ping Lin</name><name sortKey="Lu, Lin Yu" sort="Lu, Lin Yu" uniqKey="Lu L" first="Lin-Yu" last="Lu">Lin-Yu Lu</name><name sortKey="Watt, Rory M" sort="Watt, Rory M" uniqKey="Watt R" first="Rory M" last="Watt">Rory M. Watt</name><name sortKey="Wong, Kin Ling" sort="Wong, Kin Ling" uniqKey="Wong K" first="Kin-Ling" last="Wong">Kin-Ling Wong</name><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. 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